|
|
|
|
We understand that this
summary data might be inadequate to evaluate the usefulness of these treatments
in a particular case. It is provided merely as a starting point.
Please contact us for further information. We are pleased to answer your
questions.
NEUROLOGIC RESPONSE TO HDMTX-CF
IN ASTROCYTOMA
|
|
Number of Patients
|
Evaluable
|
Improved
|
No Change
|
|
Series #1: 1968-1983
|
11
|
11
|
7/11
(63.6%)
|
4/11
(36.4%)
|
|
Series #2: 1983-1985
|
19
|
14
|
13/14
(92.9%)
|
1/14
(7.1%)
|
|
Series #3: 1985-
|
57
|
57
|
38/57
(66.7)
|
15/57
(26.3%)
|
|
Total
|
87
|
82
|
58/82
(70.7%)
|
20/57
(35.0%)
|
OBJECTIVE (CT SCANNING) RESPONSE
TO HDMTX-CF IN ASTROCYTOMA
|
|
Number of Patients
|
Evaluable
|
Improved
|
No Change
|
Progressed
|
|
Series #1: 1968-1983
|
11
|
9
|
6/9
(66.7%)
|
0/9
(0%)
|
3/9 (33.3%) |
|
Series #2: 1983-1985
|
19
|
19
|
15/19
(78.9%)
|
4/19
(21.8%)
|
0/19 (0%) |
|
Series #3: 1985`
|
57
|
51
|
35/51
(68.6)
|
5/51
(9.8%)
|
11/51 (21.6%) |
|
Total
|
87
|
79
|
56/79
(70.9%)
|
9/79
(11.0%)
|
14/79 (17.7%) |
SCIENTIFIC PUBLICATIONS ON GLIOMA/ASTROCYTOMA AND HIGH DOSE
METHOTREXATE
Djerassi’s Publications on Treatment of
Brain Tumors (Glioma/Astrocytoma)
1. Djerassi,
I., Kim, J.S. and Shulman, K.: High Dose Methotrexate Citrovorum Factor
Rescue in the Management of Brain Gliomas.
Cancer Treatment Reports, 61:4, 1977.
2.
Djerassi, I., Kim, J.S. and Reggev,:
Response of Astrocytoma to High Dose Methotrexate with Citrovorum Factor Rescue. Cancer 55:2741-2747, 1985.
3.
Djerassi, I., Kim, J.S. Kassarov, L. and Reggev, : Response of Mesothelioma to Large Doses of
Methotrexate with CF Rescue (HDMTX) Used Alone or with Cisplatinum. Proc. ASCO 4: 191, 1985.
4.
Djerassi, I., Rominger, C.J., Kim, J.S. Kassarov, L., Patel, A. and
Ahmad, N.: Astrocytoma Responding to
High Dose Methotrexate CF Rescue (HDMTX-CF), Alone or Combined with
Simultaneous Small Doses of Radiation. Proc.
AACR 26:171,1985.
5. Djerassi,
I., Kim, J.S., Kassarov, L., Reggev, A.Gandhi, V., and Srivastava, B.: High
Dose Methotrexate (HDMTX) with Citrovorum Factor (CF) in Astrocytoma. ASCO, 1988.
6.
Djerassi, I., M.J. Suh, A. Lee and C.D. Kim: Objective Response of
Poor Risk Astrocytom to a combination of High Dose Methotrexate
(HDMTX) with Cisplatinum and/or
BCNU. Proc. ASCO, Vol. 10, p. 126-1991.
7.
Djerassi, I., Suh, M.J., Kim,
J.S., Kim, C.D.: High Dose Methotrexate
in Grade III Astrocytom. Proc. ASCO,
1992.
8.
Djerassi, I., Suh, M.J., Kim, J.S., Reggev, A., Kassarov, L., Kim,
C.D.: Survival of Astrocytoma Patients
Whose Treatment Included High Dose Methotrexate with Citrovorum Rescue. Proc. ASCO, Vol. 12, p. 181, 1993
Publications by Others Confirming Djerassi’s Work on Treatment of Brain Tumors
1.
Rosen, G., Ghavimi, F., Vanucci, R. Deck, M.,Tan, C. Murphy, L: Pontine Glioma. High-Dose Methotrexate and
Leucovorin Rescue. JAMA, Vol. 230, No. 8, p. 1149-1152, 1974.
2.
Allen, Jeffrey, Walker, Russell and Rosen, Gerald: Preradiation High-Dose Intravenous
Methotrexate With Leucovorin Rescue for Untreated Primary Childhood Brain
Tumors, J. of Clinical Oncology, Vol. 6, No. 4, p. 649-653, 1988.
3.
Boiardi A., Silvani, A., Croci, D., Perego, E., Solero C.L.: Neoadjuvant Chemotherapy in the Treatment of
Recurrent Glioblastomas (GBM). Ital. J.
Neurol. Sci. 13, p. 583-588, 1992.
4.
Schawabe, D., Gussetis, E., Jacobi, G., Gerein, V. Kornhuber, B: Hochdosiertes Methotrexat in Kombination
mit, 8 in 1 in der Therapie Kindlicher Grad III/IV Hirntumoren, Klin. Padiatr.
#204, p. 72-77, 1992.
- Blay, J., Conroy, T. Chevreau, C., Thyss, A., Quesnel, N., Houchingue, E., Bouabdallah, R.,
etal. High-Dose Methotrexate for
the Treatment of Primary Cerebral
Lymphomas: Asalysis of Survival
and Late Neurologic Toxicity in a Retrospective Series. J. of Clinical Oncology, Vol16, #3, p.
864-871, March, 1988.
Contact email:treatmentglioma@aol.com