Malignant brain tumors (gliomas) can rarely  be cured by surgery and/or  radiotherapy alone.  Chemotherapy, as generally available, has been of limited value.

Dr. Isaac Djerassi has perfected a form of intensive chemotherapy which is proving to be the most effective treatment for brain gliomas.  Among 200 patients with brain glioma, treated by his method, 70% have shown substantial reduction or disappearance of their tumors, with marked improvement of their symptoms  and prolonged survival.  Eighteen of 57 (31%) patients with advanced and terminal Grade III or near Grade III Glioblastoma were alive at 10 to 28 years with a median of over 10 years.  Four of the 18 long-term survivors received this chemotherapy alone with no radiation therapy at all.  Higher success rates are expected in recently diagnosed and previously untreated patients in good general condition.  The destruction of gliomas in 70% of the patients treated with high-dose methotrexate is illustrated below with the MRI pictures of the brain in a patient with malignant glioma taken before and after treatment.  In a series of 79 patients who had MRI or CT scan observable cancers, 52 patients (70.9%) had their cancers shrink in size.  These results were reported to the profession in 1988.  (See References).

The above two images show the tumor of a patient with Glioma (Astrocytoma) before (left), and after treatment with Djerassi’s chemotherapy.  The tumor, seen as a white circular shape near the center of the left-hand image, is no longer visible following treatment.

Isaac Djerassi, MD, a renown pioneer in cancer treatment, has had remarkable success in treating cancers unresponsive to chemotherapy.  This website will introduce you to him and to his techniques.

Dr. Djerassi has received some of the most prestigious professional awards and large-scale government grant support for his work over the last 30 years.  He has over 150 scientific publications to his name.  Many of Dr. Djerassi’s discoveries have been featured in the popular press, such as Reader’s Digest, Newsweek, Time Magazine, New York Times and others.

Click here to read about Dr. Djerassi in Reader’s Digest

Read about Dr. Djerassi's glioma treatment by clicking here.

Read some selected clinical data by clicking here.

Read Dr. Djerassi's chemotherapy by clicking here.

For Dr. Djerassi's history, look at his curriculum vitae by clicking here.

Most remarkable results with Dr. Djerassi’s High Dose Methotrexate chemotherapy  have been obtained by him and by others in the following types of cancer

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